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Tag: Preclinical

May 31, 2023May 31, 2023

Readily Available Dietary Supplement Reverses HIV-Related Organ Damage in Preclinical Trials

Best Nutritional Supplements by Admin0 comments

HIV-infected H9 t-cell. Credit: NIAID

MitoQ, a publicly accessible dietary supplement that acts as a mitochondrial antioxidant, was discovered through a mouse study to counteract the harmful impacts that HIV and antiretroviral therapy (ART) inflict on the mitochondria within the brain, heart, aorta, lungs, kidney, and liver.

The research team employed a molecular technique to calculate the proportion between human and murine mitochondrial (mtDNA) and nuclear DNA (ntDNA), a key indicator of mitochondrial dysfunction. A decrease in this ratio signals impaired mitochondrial function. Relative to their healthy counterparts, mice infected with HIV and treated with ART demonstrated mitochondrial dysfunction in

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